Research by Seer team members published in Nature Neuroscience

Seer team members, Pip Karoly, Dean Freestone and Mark Cook have had their collaborative research with the Czech Academy of Sciences (Czech Republic) published in Nature Neuroscience.

Their research explores ‘critical slowing’ prior to a seizure. Critical slowing is a phenomenon that occurs as a system approaches a “critical point”. In the brain, the critical point could represent a catastrophic threshold past which the brain transitions into a seizure state. This study combines animal and human data to show that early warning signals of critical slowing are present in the lead up to epileptic seizures.

Read Melbourne School of Engineering’s article in Ingenium for more about how the study findings help seizure forecasting and management.

Seer seizure forecasting research published in Lancet Neurology

Seer team members, Pip Karoly, Dean Freestone and Mark Cook have had their research published in Lancet Neurology.

Epilepsy has long been suspected to be governed by cyclic rhythms, with seizure rates rising and falling periodically over weeks, months, or even years.

The very long scales of seizure patterns seem to defy natural explanation and have sometimes been attributed to hormonal cycles or environmental factors.

The research aimed to quantify the strength and prevalence of seizure cycles at multiple temporal scales across a large cohort of people with epilepsy.

It was the largest study of seizure cycles in humans in the world, and the first to provide conclusive evidence that multi-day cycles exist for most people with epilepsy.

Read Pip Karoly’s article in The Pursuit for more about how the study findings should be applied to improve the management, treatment and care of people with epilepsy.